Calcium sulfate dihydrate Revision Date 23-Jan-2018 Handling Wear personal protective equipment/face protection. Biphasic Calcium Sulfate is composed of two phases of the well known Calcium Sulfate. The dihydrate forms of gypsum have a fairly neutral pH and about 20% water of crystallization. Standard handling procedures recommend avoiding ingestion and contact with the eyes and mucous membranes. Nanoscale elemental powders and suspensions, as alternative high surface area forms, may be considered. These may be extracted by open-cast quarrying or by deep mining. Reconstruction of large segmental bone defects in rabbit using the Masquelet technique with α-calcium sulfate hemihydrate. eCollection 2018. Calcium sulfate can also be recovered and re-used from scrap drywall at construction sites. Franz Wirsching "Calcium Sulfate" in Ullmann's Encyclopedia of Industrial Chemistry, 2012 Wiley-VCH, Weinheim. Epub 2019 Sep 8. Date of Publication: 1989 Calcium sulfate- and calcium phosphate-based bone substitutes. Fabricated forms may include pressed and cast surgical implants in various geometric shapes. Dust deposits should not be allowed to accumulate on surfaces. One particular hydrate is better known as plaster of Paris, and another occurs naturally as the mineral gypsum. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Epub 2009 Oct 16. The calcium sulfate hydrates are used as a coagulant in products such as tofu. Listing and annotation: Calcium sulfate—mined Use: As a non-synthetic non-agricultural product allowed as an ingredient/processing aid in or on products labeled "organic" or "made with (specified organic ingredients/food groups)". A dual PMMA/calcium sulfate carrier of vancomycin is more effective than PMMA-vancomycin at inhibiting Staphylococcus aureus growth in vitro. Despite these advantages, calcium sulfate has never attracted the same degree of research interest as have other biomaterials. Orthop Clin North Am. Extended setting time in vancomycin loaded groups, the only significant difference compared with pure calcium sulfate group, increase proper handling duration of premixed cements in injecting occasion, but, in those occasions with cement blocks or beads made during the operation, more time is needed before the mantle is hardened. This issue is particular with the phosphate by-product, since phosphate ores naturally contain uranium and its decay products such as radium-226, lead-210 and polonium-210.  |   |  The solubility of calcium sulfate decreases thus when temperature increases. doi: 10.1615/jlongtermeffmedimplants.v15.i6.30. We also produce Calcium Sulfate Solution. nH2O where n = 0 to 0.05) is produced. Spacers; Calcium Sulfate; Bone Cement; Implant Removal; Biologics. γ-Anhydrite reacts slowly with water to return to the dihydrate state, a property exploited in some commercial desiccants. It has been shown that tissue will often migrate over calcium sulfate if primary closure cannot be obtained, which provides further evidence of its biocompatibility. Available in regular and coarse grinds, Calcium Sulfate (Feed Grade Gypsum): Supplies, on average, 17% combined sulfur and available calcium at approximately 21%, which can reduce or even eliminate the need for adding calcium carbonate to the ration; Is an economical feed supplement Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview. Mimicry of the mineral phase of bone. α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo. Chen C, Zhu C, Hu X, Yu Q, Zheng Q, Tao S, Fan L. Drug Des Devel Ther. [12] It has been used in bone regeneration as a graft material and graft binder/extender and as a barrier in guided tissue regeneration. Epub 2020 Mar 11. A clinical and histological case series study on calcium sulfate for maxillary sinus floor augmentation and delayed placement of dental implants. ExactechGPS System; ExactechGPS Knee Applications; ExactechGPS Shoulder Application; ExactechGPS No Capital Process; Infection-Related Solutions. Do not breathe dust. The safety of ready-to-eat meat products such as frankfurters can be enhanced by treating with approved antimicrobial substances to control the growth of Listeria monocytogenes. Calcium sulphate. Its presence Calcium sulfate dihydrate has a wide variety of uses. Eye, skin, nose, throat, and upper respiratory irritation can occur with dust exposure. This page was last edited on 24 December 2020, at 15:13. J Biomed Mater Res B Appl Biomater. World production of natural gypsum is around 127 million tonnes per annum.[15]. It exists in two forms (alpha and beta), which differ greatly in physical properties. The sulphate ion has caused gastro-intestinal disturbance in humans following large oral doses. 2002 Oct;22(5):503-8. 10.1615/jlongtermeffmedimplants.v15.i6.30. It exists in two forms (alpha and beta), which differ greatly in physical properties. 2020 Apr;10(4):552-560. doi: 10.1002/2211-5463.12809. Gypsum (Calcium Sulfate Dihydrate) This product can release nuisance dust in handling or during use. Maxillary sinus augmentation using prehardened calcium sulfate: a case report. Exposure of calcium sulfate paste to blood or body fluids results in significant extension of setting time along with lowered mechanical strength. Please follow MSDS handling instructions. We evaluated the effectiveness of acidic calcium sulfate with propionic and lactic acid, potassium lactate, or lactic acid …. Calcium sulfate is a common laboratory and industrial chemical. Int J Periodontics Restorative Dent. Calcium sulfate (or calcium sulphate) is the inorganic compound with the formula CaSO4 and related hydrates.  |  2018 Oct 2;12:3269-3287. doi: 10.2147/DDDT.S173289. Get the latest public health information from CDC:, Get the latest research information from NIH:, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: Calcium sulfate has a long history of use in medicine and dentistry. Avoid contact with skin, eyes or clothing. Int J Periodontics Restorative Dent. The variable composition of the hemihydrate and γ-anhydrite, and their easy inter-conversion, is due to their nearly identical crystal structures containing "channels" that can accommodate variable amounts of water, or other small molecules such as methanol. [10], For the FDA, it is permitted in Cheese and Related Cheese Products; Cereal Flours; Bakery Products; Frozen Desserts; Artificial Sweeteners for Jelly & Preserves; Condiment Vegetables; and Condiment Tomatoes and some candies. It does not evoke a significant host response and creates a calcium-rich milieu in the area of implantation.[13]. If burning, redness, itching, pain or other Linde (ed.) Registration dossier . 2009. "CRC Handbook of Chemistry and Physics", 83rd Edition, CRC Press, 2002. The retrograde solubility of calcium sulfate is also responsible for its precipitation in the hottest zone of heating systems and for its contribution to the formation of scale in boilers along with the precipitation of calcium carbonate whose solubility also decreases when CO2 degasses from hot water or can escape out of the system. This site needs JavaScript to work properly. Limited studies involving the repeated inhalation of an [unspecified] calcium sulphate failed to identify any particular target organs in monkeys, rats and hamsters. Orthop Surg. It is an unusually biocompatible material and is completely resorbed following implantation. Section 6: Accidental Release Measures. Avoid dust formation. Finish cleaning by spreading water on the contaminated surface and dispose of Calcium sulfate according to legal requirements. Compare Products: Select up to 4 products. Although exact temperatures will vary depending upon vapor pressure, relative humidity, etc., gypsum starts to lose its water of crystallization as it is heated above –50ºC (122ºF). It has been used in bone regeneration as a graft material and graft binder/extender and as a barrier in guided tissue regeneration. Zhang H, Yang L, Yang XG, Wang F, Feng JT, Hua KC, Li Q, Hu YC. EFFECTS OF OVEREXPOSURE: ACUTE: EYES: Direct contact can cause mechanical irritation of eyes. It is an unusually biocompatible material and is completely resorbed following implantation. *Please select more than one item to compare Learn more. These applications exploit the fact that calcium sulfate which has been powdered and calcined forms a moldable paste upon hydration and hardens as crystalline calcium sulfate dihydrate. Continuing our goal to provide infection-related solutions, Exactech introduces InterSep Calcium Sulfate – a 100% synthetic calcium sulfate bone void filler engineered to fully resorb and replace bone during the healing process. Anhydrous calcium sulfate, Anhydrous gypsum, Anhydrous sulfate of lime, Calcium salt of sulfuric acid [Note: Gypsum is the dihydrate form and Plaster of Paris is the hemihydrate form.] It has been used in bone regeneration as a graft material and graft binder/extender and as a barrier in guided tissue regeneration. It is also convenient that calcium sulfat… Registration dossier . Scarano A, Orsini G, Pecora G, Iezzi G, Perrotti V, Piattelli A. Implant Dent. Wahl P, Rönn K, Bohner M, Decosterd LA, Meier C, Schläppi M, Festa S, Gautier E. J Bone Jt Infect. So, to dissolve higher amounts of calcium sulfate or calcium hydroxide in water, it is necessary to cool down the solution close to its freezing point instead of increasing its temperature. These corrosion data are mainly based on results of general corrosion laboratory tests, carried out with pure chemicals and water solutions nearly saturated with air (the corrosion rate can be quite different if the solution is free from oxygen). With more than 100 years of documented clinical success, (Dreesmann 1892, Thomas and Puleo 2008) it has a longer history of clinical use when compared to most currently available biomaterials. Calcium sulfate (CS) features a unique position among all regenerative bone graft substitutes. 2002. Calcium Sulfate Fillers are made from high purity, naturally occurring gypsum (CaSO4•2H2O). Calcium sulfate can be used as a delivery vehicle for growth factors and antibiotics, although this application has not been thoroughly exploited in the clinical setting. Dasmah A, Hallman M, Sennerby L, Rasmusson L. Clin Implant Dent Relat Res. This contra-intuitive solubility behaviour is called retrograde solubility. Plaster of Paris is a mixture of powdered and heat-treated gypsum. Name: Price: Quantity: 1 Pound - Calcium Sulfate Dihydrate $ 2.50 : 2 Pounds - Calcium Sulfate Dihydrate $ 3.50 : 5 Pounds - Calcium Sulfate Dihydrate Calcium Sulfate Suppliers USA. Calcium Sulfate; Foot and Ankle Resource Library; ExactechGPS. Recently, however, it has enjoyed a resurgence of sorts in the areas of periodontology, sinus augmentation, and orthopedic surgery. [16], InChI=1S/Ca.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2, InChI=1/Ca.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2, Except where otherwise noted, data are given for materials in their, Hydration states and crystallographic structures, D.R. In the form of γ-anhydrite (the nearly anhydrous form), it is used as a desiccant.While natural, unrefined calcium sulfate is a translucent, crystalline white rock, a form sold under the name Drierite® appears blue or pink due to impregnation with cobalt chloride, which functions as a moisture indicator. Images suggest the mineral is gypsum. If the system is cooled, the dissolution equilibrium will evolve towards the right according to the Le Chatelier principle and calcium sulfate will dissolve more easily. Therefore, calcium sulfate is also one of the primary salts used for the improvement of calcium levels in beer. Because deposits of calcium sulfate throughout the world are … Odorless, white powder or colorless, crystalline solid. Upon being mixed with shale or marl, and roasted, the sulfate liberates sulfur trioxide gas, a precursor in sulfuric acid production, the reaction also produces calcium silicate, a mineral phase essential in cement clinker production. [14], The main sources of calcium sulfate are naturally occurring gypsum and anhydrite, which occur at many locations worldwide as evaporites. Calcium sulfate has a long history of use in medicine and dentistry. J Biomed Mater Res B Appl Biomater. Calcium Sulfate is generally immediately available in most volumes. Exactech’s latest products are designed to deliver ease of use for surgeons. Peri-implant bone regeneration with calcium sulfate: a light and transmission electron microscopy case report. 1999 Oct;30(4):615-23. doi: 10.1016/s0030-5898(05)70114-0. Calcium sulfate is also a common component of fouling deposits in industrial heat exchangers, because its solubility decreases with increasing temperature (see the specific section on the retrograde solubility). 26–29 Of course, this is due to the high solubility of calcium sulfate dihydrate. Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.. Search for products or services, then visit the American suppliers website for prices, SDS or more information. Future research must be directed toward improving handling characteristics and strength, while preserving the biocompatibility of the material. However, the main use of calcium sulfate is to produce plaster of Paris and stucco. Another calcium compound, calcium hydroxide (Ca(OH)2, portlandite) also exhibits a retrograde solubility for the same thermodynamic reason: because its dissolution reaction is also exothermic and releases heat. These calcium ions may provide some stimulation to osteoblasts, which may account for some of the positive results reported with the material. 2009 Feb;88(2):597-610. doi: 10.1002/jbm.b.31269. Calcium Sulfate, Dihydrate Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - NIOSH-approved breathing apparatus. Clipboard, Search History, and several other advanced features are temporarily unavailable. Mobility in soil No data available. Containers of Calcium sulfate or Calcium Sulphate may explode when heated. As an immediate consequence, to proceed, the dissolution reaction needs to evacuate this heat that can be considered as a product of reaction. Calcium sulfate dihydrate (alternative CAS 10101-41-4) (CAS 13397-24-5) Aquatic Fish LC50 Fathead minnow (Pimephales promelas) > 1970 mg/l, 96 hours Persistence and degradability Calcium sulfate dissolves in water forming calcium and sulfate ions. 2011 findings by the Opportunity rover on the planet Mars show a form of calcium sulfate in a vein on the surface. Other articles where Calcium sulfate is discussed: chemical industry: Sources of sulfur: …the world, abundant supplies of calcium sulfate in any of several mineral forms can be used to make the ammonium sulfate by combining it with ammonia and water. Up to the 1970s, commercial quantities of sulfuric acid were produced in Whitehaven (Cumbria, UK) from anhydrous calcium sulfate. Calcium sulfate dihydrate, puriss., meets analytical specification of NF, E 516, 99.0-101.0% (based on anhydrous substance), 1.02160 Calcium sulfate dihydrate, precipitated EMPROVE ® ESSENTIAL Ph … In addition to natural sources, calcium sulfate is produced as a by-product in a number of processes: These precipitation processes tend to concentrate radioactive elements in the calcium sulfate product. It does not evoke a significant host response and creates a calcium-rich milieu in the area of implantation. The dissolution of the different crystalline phases of calcium sulfate in water is exothermic and releases heat (decrease in Enthalpy: ΔH < 0). It exists in two forms (alpha and beta), which differ greatly in physical properties. Calcium sulfate / gypsum . No evidence of mutagenicity was found in Ames bacterial tests. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. On heating above 250 °C, the completely anhydrous form called β-anhydrite or "natural" anhydrite is formed. Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. The raw material from which calcium sulfate is made is relatively inexpensive and abundant. You can also view suppliers in Australia, NZ or the UK. eCollection 2018. COVID-19 is an emerging, rapidly evolving situation. Reference to other sections: SECTION 7 : Handling and storage Precautions for safe handling: Avoid contact with eyes, skin, and clothing. Would you like email updates of new search results? Meng ZL, Wu ZQ, Shen BX, Li HB, Bian YY, Zeng L, Fu J, Peng L. J Orthop Surg Res. Please enable it to take advantage of the complete set of features! When sold at the anhydrous state as a desiccant with a color-indicating agent under the name Drierite, it appears blue (anhydrous) or pink (hydrated) due to impregnation with cobalt(II) chloride, which functions as a moisture indicator. Calcium sulfate: Properties and clinical applications. NLM National Institute for Occupational Safety and Health, "A refinement of the crystal structure of gypsum CaSO, "Compound Summary for CID 24497 - Calcium Sulfate", "Effect of Calcium Carbonate and Calcium Sulphate on Bone Development", "NASA Mars Opportunity rover finds mineral vein deposited by water",, Chemical articles with multiple compound IDs, Chemical articles with multiple CAS registry numbers, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License. If the temperature of the system is raised, the reaction heat cannot dissipate and the equilibrium will regress towards the left according to Le Chatelier principle. Calcium sulfate is not particularly persistent under agricultural conditions because of its solubility. [11], Calcium sulfate has a long history of use in dentistry. It is less common than for most of the salts whose dissolution reaction is endothermic (i.e., the reaction consumes heat: increase in Enthalpy: ΔH > 0) and whose solubility increases with temperature. Natural anhydrite does not react with water, even over geological timescales, unless very finely ground. 2007 Jun;16(2):195-203. doi: 10.1097/ID.0b013e3180587ad8. [Note: May have blue, gray, or reddish tinge.] Calcium Sulfate Calcium Sulphate Dihydrate SDS MSDS Sheet: Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, ... Calcium sulfate (All calcium sulfates are covered by the registration of the anhydrous form.) Bioaccumulative potential Bioaccumulation is not expected. Ensure adequate ventilation. Calcium sulfate causes permanent hardness in water. [11], It is known in the E number series as E516, and the FAO knows it as a firming agent, a flour treatment agent, a sequestrant, and a leavening agent. This process brings the sulfur in the calcium sulfate deposits into use. 1.1 This specification covers material requirements for unfabricated and fabricated forms of hydrated calcium sulfate intended for surgical implants. 2019 Oct;11(5):725-737. doi: 10.1111/os.12509. The solubility of calcium sulfate increases thus when the temperature decreases. 2012 Apr;14(2):259-65. doi: 10.1111/j.1708-8208.2009.00249.x. All forms are white solids that are poorly soluble in water. Calcium sulfate is considered non-toxic and is classified as a Generally Regarded As Safe (GRAS) food additive by the FDA. Key properties of calcium sulfate are its rapid and complete resorption with minimal inflammatory response. Calcium sulfate is a food additive used as an anticaking agent, dough conditioner, flour treatment agent, pH regulator, thickenner and yeast food. HHS MSDS and Spec Sheets can be found here. Proper calcium levels in beer can provide the following influences that are generally considered to be positive: they lower the pH, preserve mash enzymes, increase extract yield, improve yeast growth and flocculation, accelerate oxalate removal, and reduce color. Common applications: Used as a … Calcium sulfate has a long history of use in medicine and dentistry. 2019 Jun 26;14(1):192. doi: 10.1186/s13018-019-1235-5. In the form of γ-anhydrite (the anhydrous form), it is used as a desiccant. It has many uses in industry. calcium sulfate definition: 1. a white chemical substance used to make cement and plaster of Paris and to make other substances…. Calcium sulfate (CaSO4) is used as food additives as acidity regulator, firming agent, flour treatment agent, sequestrant and stabilizer 27). NIH 2018 Oct 4;3(4):212-221. doi: 10.7150/jbji.26218. Search results for calcium sulphate at Sigma-Aldrich. Luo S, Jiang T, Long L, Yang Y, Yang X, Luo L, Li J, Chen Z, Zou C, Luo S. FEBS Open Bio.